Salicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation
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چکیده
منابع مشابه
Glial cells dilate and constrict blood vessels: a mechanism of neurovascular coupling.
Neuronal activity evokes localized changes in blood flow. Although this response, termed neurovascular coupling, is widely used to monitor human brain function and diagnose pathology, the cellular mechanisms that mediate the response remain unclear. We investigated the contribution of glial cells to neurovascular coupling in the acutely isolated mammalian retina. We found that light stimulation...
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Glycogen synthase kinase-3 (GSK-3) is a multifunctional serine/threonine kinase that is usually inactivated by serine phosphorylation in response to extracellular cues. However, GSK-3 can also be activated by tyrosine phosphorylation, but little is known about the upstream signaling events and tyrosine kinase(s) involved. Here we describe a G protein signaling pathway leading to GSK-3 activatio...
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ژورنال
عنوان ژورنال: Cardiovascular Research
سال: 2009
ISSN: 1755-3245,0008-6363
DOI: 10.1093/cvr/cvp084